Drug interactions
Dabrafenib + Rivaroxaban
Severity: Major
Dabrafenib and Rivaroxaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and possibly P-gp, which can lower rivaroxaban concentrations. Reduced anticoagulant effect may lead to thromboembolic events.
What this interaction means in plain words
Dabrafenib and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Rivaroxaban belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 and P-gp, increasing rivaroxaban clearance.
What to do
Avoid if possible and choose an alternative anticoagulant less affected by induction; otherwise monitor for signs of thrombosis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Rivaroxaban?
MediHelp rates the interaction as major. Dabrafenib and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib induces CYP3A4 and possibly P-gp, which can lower rivaroxaban concentrations. Reduced anticoagulant effect may lead to thromboembolic events.
How serious is the interaction between Dabrafenib and Rivaroxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an alternative anticoagulant less affected by induction; otherwise monitor for signs of thrombosis.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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