Drug interactions
Dabrafenib + Sirolimus
Severity: Moderate
Dabrafenib and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower sirolimus blood concentrations. Reduced exposure can lead to loss of immunosuppressive efficacy, with a risk of graft rejection in transplant patients.
What this interaction means in plain words
Dabrafenib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Dabrafenib induces CYP3A4 (and possibly P-gp), increasing the metabolism and clearance of sirolimus.
What to do
Monitor sirolimus trough concentrations when starting or stopping dabrafenib and increase the sirolimus dose as needed. Re-check levels after dabrafenib is discontinued to avoid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Sirolimus?
MediHelp rates the interaction as moderate. Dabrafenib and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower sirolimus blood concentrations. Reduced exposure can lead to loss of immunosuppressive efficacy, with a risk of graft rejection in transplant patients.
How serious is the interaction between Dabrafenib and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations when starting or stopping dabrafenib and increase the sirolimus dose as needed. Re-check levels after dabrafenib is discontinued to avoid toxicity.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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