Drug interactions
Dabrafenib + Solifenacin
Severity: Moderate
Dabrafenib and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can lower solifenacin concentrations. This may reduce the effectiveness of solifenacin in treating overactive bladder.
What this interaction means in plain words
Dabrafenib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Dabrafenib induces CYP3A4, increasing the metabolic clearance of solifenacin.
What to do
Monitor for reduced bladder symptom control and raise the solifenacin dose within the labeled range if needed. Reassess when dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Solifenacin?
MediHelp rates the interaction as moderate. Dabrafenib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and can lower solifenacin concentrations. This may reduce the effectiveness of solifenacin in treating overactive bladder.
How serious is the interaction between Dabrafenib and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced bladder symptom control and raise the solifenacin dose within the labeled range if needed. Reassess when dabrafenib is stopped.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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