Drug interactions
Dabrafenib + Tacrolimus
Severity: Major
Dabrafenib and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can lower tacrolimus concentrations, risking under-immunosuppression and graft rejection. Both drugs may also prolong the QT interval.
What this interaction means in plain words
Dabrafenib and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
CYP3A4 induction by dabrafenib increases tacrolimus clearance, with additive QT effects.
What to do
Monitor tacrolimus trough levels frequently and raise the dose as needed, then reduce it again after dabrafenib is stopped. Follow the ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Tacrolimus?
MediHelp rates the interaction as major. Dabrafenib and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib induces CYP3A4 and can lower tacrolimus concentrations, risking under-immunosuppression and graft rejection. Both drugs may also prolong the QT interval.
How serious is the interaction between Dabrafenib and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels frequently and raise the dose as needed, then reduce it again after dabrafenib is stopped. Follow the ECG and electrolytes.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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