Drug interactions
Dabrafenib + Upadacitinib
Severity: Moderate
Dabrafenib and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower upadacitinib exposure, risking reduced efficacy.
What this interaction means in plain words
Dabrafenib and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Upadacitinib belongs to Musculoskeletal.
Why it happens
Dabrafenib induces CYP3A4 and increases upadacitinib clearance.
What to do
Monitor disease activity and consider an alternative therapy if response declines. Avoid combining with strong inducers where alternatives exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Upadacitinib?
MediHelp rates the interaction as moderate. Dabrafenib and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower upadacitinib exposure, risking reduced efficacy.
How serious is the interaction between Dabrafenib and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease activity and consider an alternative therapy if response declines. Avoid combining with strong inducers where alternatives exist.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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