Drug interactions
Dabrafenib + Voriconazole
Severity: Major
Dabrafenib and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases dabrafenib exposure by inhibiting CYP3A4 and CYP2C8 metabolism. Conversely, dabrafenib is an inducer that may lower voriconazole levels, risking reduced antifungal efficacy.
What this interaction means in plain words
Dabrafenib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits dabrafenib metabolism, while dabrafenib induces CYP enzymes that metabolize voriconazole.
What to do
Avoid if possible; if needed, monitor for dabrafenib toxicity such as pyrexia and skin effects and consider dose reduction. Monitor voriconazole trough levels for loss of efficacy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Voriconazole?
MediHelp rates the interaction as major. Dabrafenib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole increases dabrafenib exposure by inhibiting CYP3A4 and CYP2C8 metabolism. Conversely, dabrafenib is an inducer that may lower voriconazole levels, risking reduced antifungal efficacy.
How serious is the interaction between Dabrafenib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, monitor for dabrafenib toxicity such as pyrexia and skin effects and consider dose reduction. Monitor voriconazole trough levels for loss of efficacy.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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