Drug interactions
Dacarbazine + Denosumab
Severity: Moderate
Dacarbazine and Denosumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Denosumab labeling warns of serious infections in patients with impaired immunity. Dacarbazine causes myelosuppression and may add to infection risk.
What this interaction means in plain words
Dacarbazine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacarbazine belongs to Oncology; Denosumab belongs to Oncology.
Why it happens
Additive infection risk: denosumab alters RANKL-mediated immune signalling and dacarbazine suppresses bone marrow function.
What to do
Monitor blood counts and watch for infection. Treat infections promptly and reassess the need for denosumab if serious infections develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Dacarbazine
Frequently asked questions
Can I take Dacarbazine with Denosumab?
MediHelp rates the interaction as moderate. Dacarbazine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab labeling warns of serious infections in patients with impaired immunity. Dacarbazine causes myelosuppression and may add to infection risk.
How serious is the interaction between Dacarbazine and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection. Treat infections promptly and reassess the need for denosumab if serious infections develop.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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