Drug interactions
Dacomitinib + Doxorubicin
Severity: Minor
Dacomitinib and Doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, which contributes to doxorubicin metabolism. Clinical significance is uncertain because CYP2D6 is only a minor route of doxorubicin clearance, since other enzymes and transporters predominate.
What this interaction means in plain words
Dacomitinib and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dacomitinib belongs to Oncology; Doxorubicin belongs to Oncology.
Why it happens
Dacomitinib inhibits CYP2D6, a minor pathway of doxorubicin metabolism.
What to do
No routine adjustment is needed. Monitor for increased myelosuppression and cardiotoxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Doxorubicin?
MediHelp rates the interaction as minor. Dacomitinib and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dacomitinib strongly inhibits CYP2D6, which contributes to doxorubicin metabolism. Clinical significance is uncertain because CYP2D6 is only a minor route of doxorubicin clearance, since other enzymes and transporters predominate.
How serious is the interaction between Dacomitinib and Doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for increased myelosuppression and cardiotoxicity as usual.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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