Drug interactions
Dacomitinib + Venlafaxine
Severity: Moderate
Dacomitinib and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor and venlafaxine is converted to its active metabolite O-desmethylvenlafaxine by CYP2D6. Inhibition raises venlafaxine and lowers the metabolite, while total active moiety changes little, but a rise in parent drug may increase adverse effects such as blood pressure elevation.
What this interaction means in plain words
Dacomitinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated metabolism of venlafaxine.
What to do
Monitor blood pressure, heart rate and tolerability, and lower the venlafaxine dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Venlafaxine?
MediHelp rates the interaction as moderate. Dacomitinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib is a strong CYP2D6 inhibitor and venlafaxine is converted to its active metabolite O-desmethylvenlafaxine by CYP2D6. Inhibition raises venlafaxine and lowers the metabolite, while total active moiety changes little, but a rise in parent drug may increase adverse effects such as blood pressure elevation.
How serious is the interaction between Dacomitinib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and tolerability, and lower the venlafaxine dose if adverse effects emerge.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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