Drug interactions
Dactinomycin + Erythromycin
Severity: Moderate
Dactinomycin and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may raise dactinomycin exposure by inhibiting its efflux, potentially increasing myelosuppression and mucosal toxicity. The clinical magnitude is not well characterized.
What this interaction means in plain words
Dactinomycin and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dactinomycin belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of P-glycoprotein-mediated efflux of dactinomycin.
What to do
Monitor blood counts and signs of mucositis or other toxicity; consider an alternative antibiotic such as one with no P-gp inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Dactinomycin
- Adenovirus types 4 and 7 live + Dactinomycin Contraindicated
- Belatacept + Dactinomycin Major
- Dactinomycin + Dengue vaccine Major
- Dactinomycin + Etrasimod Major
- Dactinomycin + Fingolimod Major
- Dactinomycin + Palifermin Major
Frequently asked questions
Can I take Dactinomycin with Erythromycin?
MediHelp rates the interaction as moderate. Dactinomycin and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may raise dactinomycin exposure by inhibiting its efflux, potentially increasing myelosuppression and mucosal toxicity. The clinical magnitude is not well characterized.
How serious is the interaction between Dactinomycin and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of mucositis or other toxicity; consider an alternative antibiotic such as one with no P-gp inhibition.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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