Drug interactions
Dactinomycin + Hydroxyurea
Severity: Moderate
Dactinomycin and Hydroxyurea: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow, so combining them can cause more profound cytopenias. Infection and bleeding are the main risks.
What this interaction means in plain words
Dactinomycin and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dactinomycin belongs to Oncology; Hydroxyurea belongs to Miscellaneous.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts regularly and adjust doses or give supportive care according to counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dactinomycin
- Adenovirus types 4 and 7 live + Dactinomycin Contraindicated
- Belatacept + Dactinomycin Major
- Dactinomycin + Dengue vaccine Major
- Dactinomycin + Etrasimod Major
- Dactinomycin + Fingolimod Major
- Dactinomycin + Palifermin Major
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Dactinomycin with Hydroxyurea?
MediHelp rates the interaction as moderate. Dactinomycin and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow, so combining them can cause more profound cytopenias. Infection and bleeding are the main risks.
How serious is the interaction between Dactinomycin and Hydroxyurea?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust doses or give supportive care according to counts.
What other medicines interact with Dactinomycin?
MediHelp also lists interactions of Dactinomycin with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Dactinomycin page.
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