Drug interactions
Dactinomycin + Trastuzumab
Severity: Moderate
Dactinomycin and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab increases the incidence of neutropenia when given with myelosuppressive chemotherapy, and dactinomycin is itself myelosuppressive. Infection risk may rise, although the combination is uncommon.
What this interaction means in plain words
Dactinomycin and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dactinomycin belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression and neutropenia.
What to do
Monitor neutrophil counts and signs of infection, and use supportive care such as growth factors where indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dactinomycin
- Adenovirus types 4 and 7 live + Dactinomycin Contraindicated
- Belatacept + Dactinomycin Major
- Dactinomycin + Dengue vaccine Major
- Dactinomycin + Etrasimod Major
- Dactinomycin + Fingolimod Major
- Dactinomycin + Palifermin Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Dactinomycin with Trastuzumab?
MediHelp rates the interaction as moderate. Dactinomycin and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab increases the incidence of neutropenia when given with myelosuppressive chemotherapy, and dactinomycin is itself myelosuppressive. Infection risk may rise, although the combination is uncommon.
How serious is the interaction between Dactinomycin and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of infection, and use supportive care such as growth factors where indicated.
What other medicines interact with Dactinomycin?
MediHelp also lists interactions of Dactinomycin with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Dactinomycin page.
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