Drug interactions
Dalfampridine + Givinostat
Severity: Minor
Dalfampridine and Givinostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dalfampridine is eliminated mainly by renal OCT2 secretion and has a narrow margin for seizure risk with increased exposure. Givinostat is only a weak transporter inhibitor, so any rise in dalfampridine levels is likely small.
What this interaction means in plain words
Dalfampridine and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dalfampridine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Why it happens
Possible weak inhibition of renal transporters by givinostat reducing dalfampridine clearance.
What to do
No dose change is generally needed. Be alert for dalfampridine toxicity such as paresthesia, insomnia or seizure, especially in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dalfampridine
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Dalfampridine with Givinostat?
MediHelp rates the interaction as minor. Dalfampridine and Givinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dalfampridine is eliminated mainly by renal OCT2 secretion and has a narrow margin for seizure risk with increased exposure. Givinostat is only a weak transporter inhibitor, so any rise in dalfampridine levels is likely small.
How serious is the interaction between Dalfampridine and Givinostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Be alert for dalfampridine toxicity such as paresthesia, insomnia or seizure, especially in renal impairment.
What other medicines interact with Dalfampridine?
MediHelp also lists interactions of Dalfampridine with, for example, Trilaciclib, Alogliptin-metformin, Canagliflozin-metformin. The full list is on the Dalfampridine page.
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