Drug interactions
Dalfampridine + Metformin-repaglinide
Severity: Moderate
Dalfampridine and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both metformin and dalfampridine are eliminated partly by renal OCT2-mediated secretion, so they could compete and raise each other's exposure. Dalfampridine accumulation increases seizure risk, particularly with reduced renal function.
What this interaction means in plain words
Dalfampridine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalfampridine belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
Competition for OCT2-mediated renal tubular secretion.
What to do
Check renal function before and during combined therapy, and watch for dalfampridine neurologic toxicity and metformin adverse effects. Avoid the combination in significant renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Dalfampridine
Frequently asked questions
Can I take Dalfampridine with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Dalfampridine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both metformin and dalfampridine are eliminated partly by renal OCT2-mediated secretion, so they could compete and raise each other's exposure. Dalfampridine accumulation increases seizure risk, particularly with reduced renal function.
How serious is the interaction between Dalfampridine and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function before and during combined therapy, and watch for dalfampridine neurologic toxicity and metformin adverse effects. Avoid the combination in significant renal impairment.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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