Drug interactions
Dalteparin + Dexamethasone-tobramycin
Severity: Moderate
Dalteparin and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can raise GI bleeding risk and may alter vascular integrity, which can add to the bleeding risk of low molecular weight heparin. The effect on anticoagulant activity is inconsistent.
What this interaction means in plain words
Dalteparin and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Additive bleeding risk through mucosal injury and vascular fragility, with uncertain effects on coagulability.
What to do
Monitor for bleeding and consider gastroprotection when systemic corticosteroids are given with dalteparin. Monitor anti-Xa levels in renal impairment or if clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Dalteparin and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can raise GI bleeding risk and may alter vascular integrity, which can add to the bleeding risk of low molecular weight heparin. The effect on anticoagulant activity is inconsistent.
How serious is the interaction between Dalteparin and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider gastroprotection when systemic corticosteroids are given with dalteparin. Monitor anti-Xa levels in renal impairment or if clinically indicated.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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