Drug interactions
Dalteparin + Enalapril
Severity: Moderate
Dalteparin and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins, including low molecular weight heparins, can suppress aldosterone secretion and raise serum potassium. Together with enalapril, which also reduces aldosterone, hyperkalemia is more likely, especially with renal impairment or diabetes.
What this interaction means in plain words
Dalteparin and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Enalapril belongs to Cardiovascular.
Why it happens
Additive suppression of aldosterone by heparin and ACE inhibition, leading to potassium retention.
What to do
Monitor serum potassium and renal function, particularly if treatment lasts more than a few days. Stop or reduce potassium-raising drugs if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Enalapril?
MediHelp rates the interaction as moderate. Dalteparin and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins, including low molecular weight heparins, can suppress aldosterone secretion and raise serum potassium. Together with enalapril, which also reduces aldosterone, hyperkalemia is more likely, especially with renal impairment or diabetes.
How serious is the interaction between Dalteparin and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, particularly if treatment lasts more than a few days. Stop or reduce potassium-raising drugs if hyperkalemia develops.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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