Drug interactions
Dalteparin + Estropipate
Severity: Major
Dalteparin and Estropipate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estropipate is an estrogen that increases the risk of venous thromboembolism. Given with dalteparin, it opposes the antithrombotic purpose of treatment in patients with clots or high thrombotic risk.
What this interaction means in plain words
Dalteparin and Estropipate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic opposition: estrogens promote coagulation while the heparin inhibits it.
What to do
Avoid estrogen therapy during active thrombosis and use an alternative for menopausal symptoms. Reassess VTE risk before any continued use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Estropipate?
MediHelp rates the interaction as major. Dalteparin and Estropipate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Estropipate is an estrogen that increases the risk of venous thromboembolism. Given with dalteparin, it opposes the antithrombotic purpose of treatment in patients with clots or high thrombotic risk.
How serious is the interaction between Dalteparin and Estropipate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid estrogen therapy during active thrombosis and use an alternative for menopausal symptoms. Reassess VTE risk before any continued use.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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