Drug interactions
Dalteparin + Ethinyl estradiol-levonorgestrel
Severity: Moderate
Dalteparin and Ethinyl estradiol-levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dalteparin is an anticoagulant used to treat or prevent thrombosis, whereas estrogen-containing contraceptives raise thrombotic risk. There is no direct pharmacokinetic interaction, but the contraceptive is generally unsuitable in active thromboembolism.
What this interaction means in plain words
Dalteparin and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
Why it happens
No direct mechanism; estrogen's prothrombotic effect opposes the therapeutic goal of anticoagulation.
What to do
Avoid estrogen-containing contraceptives in patients needing treatment for acute thromboembolism; use a progestin-only or non-hormonal method.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as moderate. Dalteparin and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dalteparin is an anticoagulant used to treat or prevent thrombosis, whereas estrogen-containing contraceptives raise thrombotic risk. There is no direct pharmacokinetic interaction, but the contraceptive is generally unsuitable in active thromboembolism.
How serious is the interaction between Dalteparin and Ethinyl estradiol-levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid estrogen-containing contraceptives in patients needing treatment for acute thromboembolism; use a progestin-only or non-hormonal method.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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