Drug interactions
Dalteparin + Factor x human
Severity: Moderate
Dalteparin and Factor x human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Human coagulation factor X is given to replace deficient factor X, whereas dalteparin works by enhancing antithrombin inhibition of factor Xa. Dalteparin may therefore blunt the hemostatic benefit of factor X replacement, risking inadequate bleeding control.
What this interaction means in plain words
Dalteparin and Factor x human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: dalteparin-potentiated antithrombin inhibits factor Xa generated from the replacement factor X.
What to do
Avoid giving dalteparin around factor X treatment when possible; if anticoagulation is essential, monitor clinical hemostasis and factor X activity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Factor x human?
MediHelp rates the interaction as moderate. Dalteparin and Factor x human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Human coagulation factor X is given to replace deficient factor X, whereas dalteparin works by enhancing antithrombin inhibition of factor Xa. Dalteparin may therefore blunt the hemostatic benefit of factor X replacement, risking inadequate bleeding control.
How serious is the interaction between Dalteparin and Factor x human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving dalteparin around factor X treatment when possible; if anticoagulation is essential, monitor clinical hemostasis and factor X activity.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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