Drug interactions
Dalteparin + Fenbufen
Severity: Moderate
Dalteparin and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen, an NSAID, impairs platelet function and can irritate the gastrointestinal mucosa, so together with dalteparin the risk of bleeding is increased, particularly gastrointestinal bleeding.
What this interaction means in plain words
Dalteparin and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of platelet cyclooxygenase and mucosal injury adds to dalteparin's anticoagulant effect.
What to do
Avoid the combination where possible and use paracetamol or another alternative for analgesia. If needed, use the lowest NSAID dose for the shortest time and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dalteparin and Fenbufen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Fenbufen?
MediHelp rates the interaction as moderate. Dalteparin and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen, an NSAID, impairs platelet function and can irritate the gastrointestinal mucosa, so together with dalteparin the risk of bleeding is increased, particularly gastrointestinal bleeding.
How serious is the interaction between Dalteparin and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol or another alternative for analgesia. If needed, use the lowest NSAID dose for the shortest time and monitor for bleeding.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
