Drug interactions
Dalteparin + Fenoprofen
Severity: Major
Dalteparin and Fenoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs impair platelet function and irritate the gastrointestinal tract, and dalteparin is an anticoagulant. The combination raises the risk of clinically significant bleeding.
What this interaction means in plain words
Dalteparin and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
Additive hemostatic effects from NSAID platelet inhibition and low molecular weight heparin anti-Xa activity.
What to do
Avoid concurrent use where possible and choose a non-NSAID analgesic. If unavoidable, monitor for bleeding and haemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Fenoprofen?
MediHelp rates the interaction as major. Dalteparin and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs impair platelet function and irritate the gastrointestinal tract, and dalteparin is an anticoagulant. The combination raises the risk of clinically significant bleeding.
How serious is the interaction between Dalteparin and Fenoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and choose a non-NSAID analgesic. If unavoidable, monitor for bleeding and haemoglobin.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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