Drug interactions
Dalteparin + Fluorouracil
Severity: Moderate
Dalteparin and Fluorouracil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluorouracil causes myelosuppression, including thrombocytopenia, and can injure the gut mucosa. When given with dalteparin, the bleeding risk is higher.
What this interaction means in plain words
Dalteparin and Fluorouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Fluorouracil belongs to Oncology.
Why it happens
Additive bleeding risk from chemotherapy-induced thrombocytopenia and mucosal toxicity with heparin anticoagulation.
What to do
Monitor platelet counts before and during cycles and reduce or hold dalteparin if platelets fall significantly. Watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dalteparin and Fluorouracil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Fluorouracil
Frequently asked questions
Can I take Dalteparin with Fluorouracil?
MediHelp rates the interaction as moderate. Dalteparin and Fluorouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluorouracil causes myelosuppression, including thrombocytopenia, and can injure the gut mucosa. When given with dalteparin, the bleeding risk is higher.
How serious is the interaction between Dalteparin and Fluorouracil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts before and during cycles and reduce or hold dalteparin if platelets fall significantly. Watch for bleeding.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
