Drug interactions
Dalteparin + Horse chestnut seed
Severity: Moderate
Dalteparin and Horse chestnut seed: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Horse chestnut contains esculin, a coumarin derivative, and may have anticoagulant or antiplatelet activity. Together with dalteparin this could raise bleeding risk, though evidence is limited.
What this interaction means in plain words
Dalteparin and Horse chestnut seed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Coumarin-like constituents (esculin) may add to anticoagulant and antiplatelet effects.
What to do
Avoid horse chestnut products during dalteparin therapy. If used, monitor for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Horse chestnut seed?
MediHelp rates the interaction as moderate. Dalteparin and Horse chestnut seed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Horse chestnut contains esculin, a coumarin derivative, and may have anticoagulant or antiplatelet activity. Together with dalteparin this could raise bleeding risk, though evidence is limited.
How serious is the interaction between Dalteparin and Horse chestnut seed?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid horse chestnut products during dalteparin therapy. If used, monitor for signs of bleeding.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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