Drug interactions
Dalteparin + Hydrochlorothiazide-olmesartan
Severity: Moderate
Dalteparin and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins can suppress aldosterone production by the adrenal gland, which may reduce potassium excretion. Combined with an angiotensin receptor blocker such as olmesartan, this can raise serum potassium, particularly in patients with kidney disease or diabetes. The thiazide component partly offsets this effect.
What this interaction means in plain words
Dalteparin and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Heparin-induced suppression of aldosterone synthesis adds to angiotensin receptor blockade, reducing renal potassium excretion.
What to do
Check serum potassium and renal function at baseline and periodically if dalteparin is given for more than a few days. Pay particular attention to patients with renal impairment, diabetes or other hyperkalemia risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Dalteparin and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins can suppress aldosterone production by the adrenal gland, which may reduce potassium excretion. Combined with an angiotensin receptor blocker such as olmesartan, this can raise serum potassium, particularly in patients with kidney disease or diabetes. The thiazide component partly offsets this effect.
How serious is the interaction between Dalteparin and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function at baseline and periodically if dalteparin is given for more than a few days. Pay particular attention to patients with renal impairment, diabetes or other hyperkalemia risk factors.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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