Drug interactions
Dalteparin + Hydrocortisone
Severity: Moderate
Dalteparin and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids can raise gastrointestinal bleeding risk and impair vascular integrity, which may add to the bleeding risk of low molecular weight heparin. The legacy suggestion of reduced anticoagulant effect is not well supported, and INR is not a useful measure for dalteparin.
What this interaction means in plain words
Dalteparin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Additive bleeding risk from steroid mucosal and vascular effects with anticoagulation.
What to do
Monitor for signs of bleeding and hemoglobin, and consider gastroprotection in patients on prolonged steroids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Hydrocortisone?
MediHelp rates the interaction as moderate. Dalteparin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids can raise gastrointestinal bleeding risk and impair vascular integrity, which may add to the bleeding risk of low molecular weight heparin. The legacy suggestion of reduced anticoagulant effect is not well supported, and INR is not a useful measure for dalteparin.
How serious is the interaction between Dalteparin and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and hemoglobin, and consider gastroprotection in patients on prolonged steroids.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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