Drug interactions
Dalteparin + Ketorolac intranasal
Severity: Major
Dalteparin and Ketorolac intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is a potent NSAID that inhibits platelet function and carries a labeled warning against use with anticoagulants because of bleeding risk. The intranasal form is absorbed systemically, so the concern applies with dalteparin.
What this interaction means in plain words
Dalteparin and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cyclooxygenase inhibition impairs platelet aggregation and damages gastric mucosa, adding to dalteparin's anticoagulant effect.
What to do
Avoid concurrent use and choose a non-NSAID analgesic such as paracetamol. If it cannot be avoided, monitor closely for bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Ketorolac intranasal?
MediHelp rates the interaction as major. Dalteparin and Ketorolac intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac is a potent NSAID that inhibits platelet function and carries a labeled warning against use with anticoagulants because of bleeding risk. The intranasal form is absorbed systemically, so the concern applies with dalteparin.
How serious is the interaction between Dalteparin and Ketorolac intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-NSAID analgesic such as paracetamol. If it cannot be avoided, monitor closely for bleeding and renal function.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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