Drug interactions
Dalteparin + Meclofenamate
Severity: Moderate
Dalteparin and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate, an NSAID, impairs platelet function and can cause gastrointestinal ulceration, increasing the bleeding risk when given with dalteparin.
What this interaction means in plain words
Dalteparin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-mediated platelet inhibition and mucosal injury add to dalteparin's anticoagulant effect.
What to do
Prefer a non-NSAID analgesic. If the combination is needed, use the lowest dose for the shortest time and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Meclofenamate?
MediHelp rates the interaction as moderate. Dalteparin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate, an NSAID, impairs platelet function and can cause gastrointestinal ulceration, increasing the bleeding risk when given with dalteparin.
How serious is the interaction between Dalteparin and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic. If the combination is needed, use the lowest dose for the shortest time and monitor for bleeding.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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