Drug interactions
Dalteparin + Parecoxib
Severity: Moderate
Dalteparin and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, a prodrug of the COX-2 inhibitor valdecoxib, has less effect on platelets than non-selective NSAIDs but can still cause gastrointestinal and renal problems. Combined with dalteparin the bleeding risk may be modestly increased.
What this interaction means in plain words
Dalteparin and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition spares platelet thromboxane but may impair mucosal protection and renal function, adding to bleeding risk with dalteparin.
What to do
Use the lowest effective parecoxib dose for the shortest time and monitor for bleeding. Check renal function, since impairment increases dalteparin accumulation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Parecoxib?
MediHelp rates the interaction as moderate. Dalteparin and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, a prodrug of the COX-2 inhibitor valdecoxib, has less effect on platelets than non-selective NSAIDs but can still cause gastrointestinal and renal problems. Combined with dalteparin the bleeding risk may be modestly increased.
How serious is the interaction between Dalteparin and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective parecoxib dose for the shortest time and monitor for bleeding. Check renal function, since impairment increases dalteparin accumulation.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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