Drug interactions
Dalteparin + Phenindione
Severity: Major
Dalteparin and Phenindione: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenindione is a vitamin K antagonist, and combining it with dalteparin adds anticoagulant effects, increasing bleeding risk. Overlap is only intended when transitioning to oral anticoagulation.
What this interaction means in plain words
Dalteparin and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive anticoagulation: vitamin K antagonism reduces clotting factor synthesis while dalteparin potentiates antithrombin inhibition of factor Xa.
What to do
Limit overlap to the bridging period and stop dalteparin once the INR is therapeutic; monitor INR and bleeding signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Phenindione?
MediHelp rates the interaction as major. Dalteparin and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenindione is a vitamin K antagonist, and combining it with dalteparin adds anticoagulant effects, increasing bleeding risk. Overlap is only intended when transitioning to oral anticoagulation.
How serious is the interaction between Dalteparin and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit overlap to the bridging period and stop dalteparin once the INR is therapeutic; monitor INR and bleeding signs.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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