Drug interactions
Dalteparin + Piperacillin-tazobactam
Severity: Moderate
Dalteparin and Piperacillin-tazobactam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose piperacillin can impair platelet function and may add to the bleeding risk of low molecular weight heparins. The effect is usually modest but may matter in renal impairment or in patients with other bleeding risks.
What this interaction means in plain words
Dalteparin and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Piperacillin-tazobactam belongs to Anti Bacterial.
Why it happens
Piperacillin impairs platelet aggregation, adding to the antithrombotic effect of dalteparin.
What to do
Monitor for bleeding and check platelet count and renal function. Check anti-Xa levels if renal impairment is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dalteparin and Piperacillin-tazobactam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Piperacillin-tazobactam
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Piperacillin-tazobactam?
MediHelp rates the interaction as moderate. Dalteparin and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose piperacillin can impair platelet function and may add to the bleeding risk of low molecular weight heparins. The effect is usually modest but may matter in renal impairment or in patients with other bleeding risks.
How serious is the interaction between Dalteparin and Piperacillin-tazobactam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check platelet count and renal function. Check anti-Xa levels if renal impairment is present.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Vancomycin, Amikacin, Antithrombin alfa. The full list is on the Piperacillin-tazobactam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
