Drug interactions
Dalteparin + Quinapril
Severity: Moderate
Dalteparin and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins can suppress aldosterone secretion, and ACE inhibitors also lower aldosterone, so combined use can raise serum potassium. Risk is higher in diabetes, renal impairment and prolonged heparin use.
What this interaction means in plain words
Dalteparin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive reduction in aldosterone-mediated potassium excretion, with heparin inhibiting adrenal aldosterone synthesis and quinapril reducing angiotensin II.
What to do
Check serum potassium and renal function at baseline and periodically during extended co-therapy, particularly in high-risk patients; manage hyperkalemia if it appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dalteparin and Quinapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Quinapril?
MediHelp rates the interaction as moderate. Dalteparin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins can suppress aldosterone secretion, and ACE inhibitors also lower aldosterone, so combined use can raise serum potassium. Risk is higher in diabetes, renal impairment and prolonged heparin use.
How serious is the interaction between Dalteparin and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function at baseline and periodically during extended co-therapy, particularly in high-risk patients; manage hyperkalemia if it appears.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
