Drug interactions
Dalteparin + Reteplase
Severity: Major
Dalteparin and Reteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase is a thrombolytic, and giving it with or after an anticoagulant such as dalteparin markedly increases the risk of serious bleeding, including intracranial hemorrhage. The combination is used only in defined settings such as acute myocardial infarction under specialist protocols.
What this interaction means in plain words
Dalteparin and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Plasminogen activation causes fibrinolysis while dalteparin inhibits clot formation via factor Xa, producing additive hemorrhagic risk.
What to do
Use only under a specialist protocol with defined timing of anticoagulant administration. Monitor closely for bleeding and neurological changes, and avoid invasive procedures.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Reteplase?
MediHelp rates the interaction as major. Dalteparin and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Reteplase is a thrombolytic, and giving it with or after an anticoagulant such as dalteparin markedly increases the risk of serious bleeding, including intracranial hemorrhage. The combination is used only in defined settings such as acute myocardial infarction under specialist protocols.
How serious is the interaction between Dalteparin and Reteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only under a specialist protocol with defined timing of anticoagulant administration. Monitor closely for bleeding and neurological changes, and avoid invasive procedures.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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