Drug interactions
Dalteparin + Telmisartan-amlodipine
Severity: Moderate
Dalteparin and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins, including low molecular weight heparins, can suppress aldosterone secretion, which may raise serum potassium. Combined with the angiotensin receptor blocker telmisartan, which also reduces aldosterone effect, the risk of hyperkalemia increases, particularly in renal impairment or diabetes.
What this interaction means in plain words
Dalteparin and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Both agents reduce aldosterone-mediated potassium excretion, producing additive hyperkalemia risk.
What to do
Monitor serum potassium and renal function, especially if dalteparin is given for more than a few days. Reassess therapy if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Dalteparin and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins, including low molecular weight heparins, can suppress aldosterone secretion, which may raise serum potassium. Combined with the angiotensin receptor blocker telmisartan, which also reduces aldosterone effect, the risk of hyperkalemia increases, particularly in renal impairment or diabetes.
How serious is the interaction between Dalteparin and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, especially if dalteparin is given for more than a few days. Reassess therapy if potassium rises.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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