Drug interactions
Dalteparin + Vorapaxar
Severity: Major
Dalteparin and Vorapaxar: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is a PAR-1 antagonist that raises bleeding risk, including intracranial hemorrhage. Adding dalteparin further increases bleeding risk.
What this interaction means in plain words
Dalteparin and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effects of PAR-1 platelet thrombin receptor antagonism and anticoagulation.
What to do
Avoid unless benefit clearly outweighs risk, and monitor closely for bleeding. Vorapaxar is contraindicated in patients with prior stroke or intracranial hemorrhage.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Vorapaxar?
MediHelp rates the interaction as major. Dalteparin and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar is a PAR-1 antagonist that raises bleeding risk, including intracranial hemorrhage. Adding dalteparin further increases bleeding risk.
How serious is the interaction between Dalteparin and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless benefit clearly outweighs risk, and monitor closely for bleeding. Vorapaxar is contraindicated in patients with prior stroke or intracranial hemorrhage.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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