Drug interactions
Danazol + Dapsone
Severity: Minor
Danazol and Dapsone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may increase dapsone exposure. Higher levels could add to hematologic toxicity, and danazol itself can cause hematologic effects.
What this interaction means in plain words
Danazol and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol inhibits CYP3A4, decreasing dapsone clearance.
What to do
Monitor complete blood count and signs of methemoglobinemia. Reduce the dapsone dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Danazol with Dapsone?
MediHelp rates the interaction as minor. Danazol and Dapsone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a CYP3A4 inhibitor and may increase dapsone exposure. Higher levels could add to hematologic toxicity, and danazol itself can cause hematologic effects.
How serious is the interaction between Danazol and Dapsone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood count and signs of methemoglobinemia. Reduce the dapsone dose if adverse effects occur.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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