Drug interactions
Danazol + Dasatinib
Severity: Moderate
Danazol and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may increase dasatinib exposure. Higher dasatinib levels raise the risk of myelosuppression, fluid retention and QT prolongation.
What this interaction means in plain words
Danazol and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of dasatinib.
What to do
Monitor blood counts, fluid status and QTc, and consider a dasatinib dose reduction. Consider an alternative to danazol if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Danazol with Dasatinib?
MediHelp rates the interaction as moderate. Danazol and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may increase dasatinib exposure. Higher dasatinib levels raise the risk of myelosuppression, fluid retention and QT prolongation.
How serious is the interaction between Danazol and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, fluid status and QTc, and consider a dasatinib dose reduction. Consider an alternative to danazol if feasible.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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