Drug interactions
Danazol + Dronabinol
Severity: Moderate
Danazol and Dronabinol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may raise dronabinol concentrations. This can intensify psychoactive effects such as dizziness, sedation, anxiety, confusion and tachycardia.
What this interaction means in plain words
Danazol and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of dronabinol by danazol.
What to do
Start with a reduced dronabinol dose and monitor for excessive CNS and cardiovascular effects. Reduce dose further if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Danazol with Dronabinol?
MediHelp rates the interaction as moderate. Danazol and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may raise dronabinol concentrations. This can intensify psychoactive effects such as dizziness, sedation, anxiety, confusion and tachycardia.
How serious is the interaction between Danazol and Dronabinol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a reduced dronabinol dose and monitor for excessive CNS and cardiovascular effects. Reduce dose further if adverse effects occur.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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