Drug interactions
Danazol + Dronedarone
Severity: Major
Danazol and Dronedarone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4 and may increase dronedarone concentrations. This can increase QT prolongation, bradycardia and other dose-related toxicity.
What this interaction means in plain words
Danazol and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by danazol reduces dronedarone metabolism.
What to do
Avoid if possible; otherwise monitor ECG and heart rate closely. Consider an alternative to danazol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Danazol with Dronedarone?
MediHelp rates the interaction as major. Danazol and Dronedarone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Danazol inhibits CYP3A4 and may increase dronedarone concentrations. This can increase QT prolongation, bradycardia and other dose-related toxicity.
How serious is the interaction between Danazol and Dronedarone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG and heart rate closely. Consider an alternative to danazol.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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