Drug interactions
Danazol + Eplerenone
Severity: Major
Danazol and Eplerenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and can raise eplerenone concentrations, increasing the risk of hyperkalemia. Eplerenone labeling restricts its dose with moderate CYP3A4 inhibitors and contraindicates strong ones.
What this interaction means in plain words
Danazol and Eplerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of eplerenone.
What to do
Prefer an alternative to one of the drugs; if combined, limit the eplerenone dose per labeling and monitor serum potassium and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Danazol with Eplerenone?
MediHelp rates the interaction as major. Danazol and Eplerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Danazol is a CYP3A4 inhibitor and can raise eplerenone concentrations, increasing the risk of hyperkalemia. Eplerenone labeling restricts its dose with moderate CYP3A4 inhibitors and contraindicates strong ones.
How serious is the interaction between Danazol and Eplerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to one of the drugs; if combined, limit the eplerenone dose per labeling and monitor serum potassium and renal function.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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