Drug interactions
Danazol + Ethinyl estradiol-drospirenone
Severity: Moderate
Danazol and Ethinyl estradiol-drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and has androgenic and antigonadotropic effects that oppose the contraceptive's hormonal actions. Combining them offers no therapeutic rationale and may alter ethinyl estradiol exposure and increase adverse effects such as lipid changes and thrombotic risk.
What this interaction means in plain words
Danazol and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol weakly inhibits CYP3A4 and has pharmacodynamic androgenic and antiestrogenic activity.
What to do
Avoid routine co-use unless specifically intended; if used together, monitor for estrogenic adverse effects, blood pressure and lipids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Danazol with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as moderate. Danazol and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak CYP3A4 inhibitor and has androgenic and antigonadotropic effects that oppose the contraceptive's hormonal actions. Combining them offers no therapeutic rationale and may alter ethinyl estradiol exposure and increase adverse effects such as lipid changes and thrombotic risk.
How serious is the interaction between Danazol and Ethinyl estradiol-drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-use unless specifically intended; if used together, monitor for estrogenic adverse effects, blood pressure and lipids.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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