Drug interactions
Danazol + Flibanserin
Severity: Moderate
Danazol and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and may raise flibanserin concentrations, increasing the risk of hypotension, syncope and sedation.
What this interaction means in plain words
Danazol and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated flibanserin metabolism.
What to do
Monitor for dizziness, hypotension and sedation, and counsel the patient about taking flibanserin at bedtime.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Danazol with Flibanserin?
MediHelp rates the interaction as moderate. Danazol and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and may raise flibanserin concentrations, increasing the risk of hypotension, syncope and sedation.
How serious is the interaction between Danazol and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, hypotension and sedation, and counsel the patient about taking flibanserin at bedtime.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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