Drug interactions
Danazol + Insulin glargine
Severity: Moderate
Danazol and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol, an androgenic steroid, can alter glucose metabolism and in some patients cause insulin resistance, so glycemic control may change. The direction and size of effect vary between patients, and diabetic control may need readjustment.
What this interaction means in plain words
Danazol and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic effects of danazol can induce insulin resistance and glucose intolerance; the exact mechanism is not fully established.
What to do
Monitor blood glucose closely when danazol is started or stopped, and adjust insulin glargine dosing based on readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Danazol with Insulin glargine?
MediHelp rates the interaction as moderate. Danazol and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol, an androgenic steroid, can alter glucose metabolism and in some patients cause insulin resistance, so glycemic control may change. The direction and size of effect vary between patients, and diabetic control may need readjustment.
How serious is the interaction between Danazol and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when danazol is started or stopped, and adjust insulin glargine dosing based on readings.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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