Drug interactions
Danazol + Itraconazole
Severity: Moderate
Danazol and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and is also a CYP3A4 substrate. Itraconazole may raise danazol levels, and danazol may slightly raise itraconazole levels. The effect on itraconazole is expected to be small.
What this interaction means in plain words
Danazol and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mutual CYP3A4 inhibition; itraconazole is a strong inhibitor of danazol metabolism.
What to do
Monitor for danazol adverse effects such as androgenic effects and liver enzyme elevation. Check liver function periodically if therapy is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Danazol with Itraconazole?
MediHelp rates the interaction as moderate. Danazol and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and is also a CYP3A4 substrate. Itraconazole may raise danazol levels, and danazol may slightly raise itraconazole levels. The effect on itraconazole is expected to be small.
How serious is the interaction between Danazol and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for danazol adverse effects such as androgenic effects and liver enzyme elevation. Check liver function periodically if therapy is prolonged.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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