Drug interactions
Danazol + Lovastatin
Severity: Major
Danazol and Lovastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can increase lovastatin levels and has been associated with myopathy and rhabdomyolysis when combined with statins. The risk is greater at higher statin doses.
What this interaction means in plain words
Danazol and Lovastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Danazol inhibits CYP3A4, reducing lovastatin first-pass metabolism.
What to do
Avoid the combination where possible, or use the lowest lovastatin dose with monitoring for muscle symptoms. Consider a statin not metabolized by CYP3A4.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Danazol with Lovastatin?
MediHelp rates the interaction as major. Danazol and Lovastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Danazol can increase lovastatin levels and has been associated with myopathy and rhabdomyolysis when combined with statins. The risk is greater at higher statin doses.
How serious is the interaction between Danazol and Lovastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest lovastatin dose with monitoring for muscle symptoms. Consider a statin not metabolized by CYP3A4.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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