Drug interactions
Danazol + Midazolam
Severity: Moderate
Danazol and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and can increase midazolam concentrations, particularly after oral dosing. This may prolong or deepen sedation and increase the risk of respiratory depression.
What this interaction means in plain words
Danazol and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated first-pass and hepatic metabolism of midazolam by danazol.
What to do
Use a reduced midazolam dose and titrate slowly, especially with oral administration. Monitor sedation level and respiratory function for a longer period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Danazol with Midazolam?
MediHelp rates the interaction as moderate. Danazol and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and can increase midazolam concentrations, particularly after oral dosing. This may prolong or deepen sedation and increase the risk of respiratory depression.
How serious is the interaction between Danazol and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced midazolam dose and titrate slowly, especially with oral administration. Monitor sedation level and respiratory function for a longer period.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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