Drug interactions
Danazol + Ribociclib
Severity: Moderate
Danazol and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4, so it may raise ribociclib exposure. This could increase QT prolongation, neutropenia and hepatotoxicity.
What this interaction means in plain words
Danazol and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4, reducing ribociclib clearance.
What to do
Monitor ECG, electrolytes and blood counts, and reduce the ribociclib dose if adverse effects arise. Prefer an alternative to danazol where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Danazol with Ribociclib?
MediHelp rates the interaction as moderate. Danazol and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol inhibits CYP3A4, so it may raise ribociclib exposure. This could increase QT prolongation, neutropenia and hepatotoxicity.
How serious is the interaction between Danazol and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, electrolytes and blood counts, and reduce the ribociclib dose if adverse effects arise. Prefer an alternative to danazol where possible.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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