Drug interactions
Danazol + Rimegepant
Severity: Minor
Danazol and Rimegepant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and may modestly raise rimegepant exposure. The clinical effect is expected to be small, since rimegepant is well tolerated at higher exposures.
What this interaction means in plain words
Danazol and Rimegepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP3A4-mediated metabolism of rimegepant by danazol.
What to do
No routine dose change is needed. Be aware of possible increased rimegepant adverse effects such as nausea or hypersensitivity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rimegepant
Frequently asked questions
Can I take Danazol with Rimegepant?
MediHelp rates the interaction as minor. Danazol and Rimegepant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and may modestly raise rimegepant exposure. The clinical effect is expected to be small, since rimegepant is well tolerated at higher exposures.
How serious is the interaction between Danazol and Rimegepant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Be aware of possible increased rimegepant adverse effects such as nausea or hypersensitivity.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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