Drug interactions
Danazol + Rivaroxaban
Severity: Moderate
Danazol and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a moderate CYP3A4 inhibitor and may raise rivaroxaban levels. It can also have prothrombotic or haemostatic effects, complicating the picture.
What this interaction means in plain words
Danazol and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of rivaroxaban.
What to do
Monitor for bleeding and clinical response; consider an alternative if renal impairment is also present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Danazol with Rivaroxaban?
MediHelp rates the interaction as moderate. Danazol and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a moderate CYP3A4 inhibitor and may raise rivaroxaban levels. It can also have prothrombotic or haemostatic effects, complicating the picture.
How serious is the interaction between Danazol and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and clinical response; consider an alternative if renal impairment is also present.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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