Drug interactions
Danazol + Rosiglitazone
Severity: Moderate
Danazol and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol, an androgenic agent, can cause insulin resistance and impair glucose tolerance. This would more likely oppose rosiglitazone and worsen glycemic control than enhance its effect.
What this interaction means in plain words
Danazol and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic effects of danazol reduce insulin sensitivity, antagonizing rosiglitazone.
What to do
Monitor blood glucose when danazol is started or stopped. Adjust the antidiabetic dose according to glycemic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Danazol with Rosiglitazone?
MediHelp rates the interaction as moderate. Danazol and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol, an androgenic agent, can cause insulin resistance and impair glucose tolerance. This would more likely oppose rosiglitazone and worsen glycemic control than enhance its effect.
How serious is the interaction between Danazol and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started or stopped. Adjust the antidiabetic dose according to glycemic response.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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