Drug interactions
Danazol + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Minor
Danazol and Sofosbuvir-velpatasvir-voxilaprevir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and may slightly increase velpatasvir and voxilaprevir exposure. The effect is not expected to be clinically important.
What this interaction means in plain words
Danazol and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol weakly inhibits CYP3A4, which plays a minor role in the metabolism of velpatasvir and voxilaprevir.
What to do
No dose adjustment is needed. Routine monitoring during HCV therapy is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Danazol with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as minor. Danazol and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and may slightly increase velpatasvir and voxilaprevir exposure. The effect is not expected to be clinically important.
How serious is the interaction between Danazol and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Routine monitoring during HCV therapy is sufficient.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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